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Quantitative MRI and strength measurements in the assessment of muscle quality in Duchenne muscular dystrophy.
- Source :
-
Neuromuscular disorders : NMD [Neuromuscul Disord] 2014 May; Vol. 24 (5), pp. 409-16. Date of Electronic Publication: 2014 Feb 08. - Publication Year :
- 2014
-
Abstract
- The purpose of this study was to assess leg muscle quality and give a detailed description of leg muscle involvement in a series of Duchenne muscular dystrophy patients using quantitative MRI and strength measurements. Fatty infiltration, as well as total and contractile (not fatty infiltrated) cross sectional areas of various leg muscles were determined in 16 Duchenne patients and 11 controls (aged 8-15). To determine specific muscle strength, four leg muscle groups (quadriceps femoris, hamstrings, anterior tibialis and triceps surae) were measured and related to the amount of contractile tissue. In patients, the quadriceps femoris showed decreased total and contractile cross sectional area, attributable to muscle atrophy. The total, but not the contractile, cross sectional area of the triceps surae was increased in patients, corresponding to hypertrophy. Specific strength decreased in all four muscle groups of Duchenne patients, indicating reduced muscle quality. This suggests that muscle hypertrophy and fatty infiltration are two distinct pathological processes, differing between muscle groups. Additionally, the quality of remaining muscle fibers is severely reduced in the legs of Duchenne patients. The combination of quantitative MRI and quantitative muscle testing could be a valuable outcome parameter in longitudinal studies and in the follow-up of therapeutic effects.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Adipose Tissue pathology
Adolescent
Adrenal Cortex Hormones therapeutic use
Child
Humans
Hypertrophy pathology
Hypertrophy physiopathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging methods
Male
Muscle Strength
Muscular Dystrophy, Duchenne drug therapy
Organ Size
Quadriceps Muscle pathology
Quadriceps Muscle physiopathology
Leg
Muscle, Skeletal pathology
Muscle, Skeletal physiopathology
Muscular Dystrophy, Duchenne pathology
Muscular Dystrophy, Duchenne physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2364
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuromuscular disorders : NMD
- Publication Type :
- Academic Journal
- Accession number :
- 24613733
- Full Text :
- https://doi.org/10.1016/j.nmd.2014.01.015