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Pd(0)-Catalyzed radical aryldifluoromethylation of activated alkenes.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2014 Apr 21; Vol. 50 (31), pp. 4108-11. - Publication Year :
- 2014
-
Abstract
- A Pd(0)-catalyzed intramolecular aryldifluoromethylation of activated alkenes under mild reaction conditions has been developed. This reaction provides a new method for construction of a variety of difluoromethylated oxindoles. Mechanistic investigations indicate that a difluoromethyl radical, which was triggered by Pd(0), initiated the cascade sequence through an addition to the alkene.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 50
- Issue :
- 31
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 24622897
- Full Text :
- https://doi.org/10.1039/c3cc49315f