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Cortical sources of resting-state EEG rhythms in "experienced" HIV subjects under antiretroviral therapy.
- Source :
-
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2014 Sep; Vol. 125 (9), pp. 1792-802. Date of Electronic Publication: 2014 Feb 12. - Publication Year :
- 2014
-
Abstract
- Objective: Treatment-naïve patients with human immunodeficiency virus (HIV) are characterized by diffuse abnormalities of resting-state cortical electroencephalographic (EEG) rhythms (Babiloni et al., 2012a). Here, we tested the hypothesis that these EEG rhythms vary as a function of the systemic immune activity and antiretroviral therapy (ART) in HIV patients.<br />Methods: Resting-state eyes-closed EEG data were recorded in 68 ART-HIV patients (mini mental state evaluation (MMSE) of 27.5 ± 0.3 SEM), in 60 treatment-naïve HIV subjects (MMSE of 27.5 ± 0.4 SEM) and in 75 age-matched cognitively normal subjects (MMSE of 29.3 ± 0.1 SEM). Based on the CD4 lymphocytes' count, we divided ART-HIV subjects into two subgroups: those with CD4>500 cells/μl (ART-HIV+) and those with CD4<500 cells/μl (ART-HIV-). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-12 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG sources were estimated by LORETA software.<br />Results: Widespread theta, alpha, and beta sources were lower in ART-HIV subjects than in control subjects. Furthermore, occipital and temporal alpha 1 sources were lower in treatment-naïve HIV than in ART-HIV subjects. Moreover, the opposite was true for widespread pathological delta sources. Finally, parietal, occipital, and temporal alpha 1 sources were lower in ART-HIV- than in ART-HIV+ subjects.<br />Conclusions: In ART-HIV subjects, cortical sources of resting-state alpha rhythms are related to systemic immune activity and cART.<br />Significance: This EEG procedure may produce biomarkers of treatment response in patients' brain compartments for longitudinal clinical studies.<br /> (Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
CD4 Lymphocyte Count
Cerebral Cortex physiopathology
Cross-Sectional Studies
Female
HIV Infections immunology
Humans
Male
Middle Aged
Neuropsychological Tests
Tomography
Viral Load
Antiretroviral Therapy, Highly Active
Electroencephalography
HIV Infections drug therapy
HIV Infections physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8952
- Volume :
- 125
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 24631008
- Full Text :
- https://doi.org/10.1016/j.clinph.2014.01.024