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The genetic variation of ARRB2 is associated with late-onset Alzheimer's disease in Han Chinese.
- Source :
-
Current Alzheimer research [Curr Alzheimer Res] 2014 May; Vol. 11 (4), pp. 408-12. - Publication Year :
- 2014
-
Abstract
- Emerging evidence indicates that β-arrestin 2, an important regulator of G protein coupled receptors, is involved in the pathogenesis of Alzheimer's disease (AD). The aim of this study was to investigate the association between β-arrestin 2 gene (ARRB2) variation and the risk of late-onset AD (LOAD). A total of 1132 LOAD patients and 1158 healthy controls from the Han Chinese population were included in this study. Initially, four common single nucleotide polymorphisms (SNPs) (rs3786047, rs16954146, rs1045280 and rs2271167) were selected by consulting the Han Chinese from Beijing genotype data in HapMap database. Considering the fact that these four SNPs were located in one haplotype block and any two of them were in almost complete linkage disequilibrium (D'=1, r2≥0.897), we chose rs1045280 (a coding- synonymous variant) that covered all the common genetic variations in ARRB2 with r2≥0.8 as the tag SNP (tSNP) for the subsequent genotyping. Our results showed that the minor allele of rs1045280 was associated with an increased LOAD risk after adjusting for age, gender, educational level, and the apolipoprotein E (APOE) ε4 status under dominant (OR=1.291; 95% CI: 1.063-1.568; Bonferroni-corrected P=0.03) and additive (OR=1.269; 95% CI: 1.069-1.507; Bonferroni- corrected P=0.018) models. Meanwhile, when these data were stratified by APOE ε4 status, this association was evident only in APOE ε4 carriers (OR=1.617; 95% CI: 1.01-2.588; P=0.045). In summary, this study provide the first evidence that the tSNP of ARRB2 significantly increases LOAD risk in Han Chinese, suggesting ARRB2 may represent a susceptibility gene for LOAD.
- Subjects :
- Age Factors
Age of Onset
Aged
Apolipoprotein E4 genetics
Asian People genetics
China
Educational Status
Female
Genotyping Techniques
Humans
Linkage Disequilibrium
Male
Sex Factors
beta-Arrestin 2
beta-Arrestins
Alzheimer Disease genetics
Arrestins genetics
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5828
- Volume :
- 11
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current Alzheimer research
- Publication Type :
- Academic Journal
- Accession number :
- 24635845
- Full Text :
- https://doi.org/10.2174/1567205011666140317095014