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Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.
- Source :
-
Gut microbes [Gut Microbes] 2014 Jan-Feb; Vol. 5 (1), pp. 28-39. Date of Electronic Publication: 2013 Sep 25. - Publication Year :
- 2014
-
Abstract
- The intestinal microbiota changes dynamically from birth to adulthood. In this study we identified γ-Proteobacteria as a dominant phylum present in newborn mice that is suppressed in normal adult microbiota. The transition from a neonatal to a mature microbiota was in part regulated by induction of a γ-Proteobacteria-specific IgA response. Neocolonization experiments in germ-free mice further revealed a dominant Proteobacteria-specific IgA response triggered by the immature microbiota. Finally, a role for B cells in the regulation of microbiota maturation was confirmed in IgA-deficient mice. Mice lacking IgA had persistent intestinal colonization with γ-Proteobacteria that resulted in sustained intestinal inflammation and increased susceptibility to neonatal and adult models of intestinal injury. Collectively, these results identify an IgA-dependent mechanism responsible for the maturation of the intestinal microbiota.
- Subjects :
- Animals
Colitis genetics
Colitis microbiology
Female
Humans
Intestines microbiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Proteobacteria classification
Proteobacteria genetics
Proteobacteria isolation & purification
Antibodies, Bacterial immunology
Colitis immunology
Immunoglobulin A immunology
Intestines growth & development
Intestines immunology
Microbiota
Proteobacteria immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1949-0984
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gut microbes
- Publication Type :
- Academic Journal
- Accession number :
- 24637807
- Full Text :
- https://doi.org/10.4161/gmic.26489