Associations of single nucleotide polymorphisms with malignant and borderline bone tumors.

Authors :: Kushlinskii NE
Tivofeev YS
Generozov EV
Naumov VA
Soloviev YN
Boulytcheva IV
Aliev MD
Source :: Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2013 Oct (10), pp. 58-60, 22-4.
Publication Year :: 2013
Abstract: Bone neoplasms - are a rare group of diseases, which ethiology and pathogenesis are not fully understood. We have studied 6 single nucleotide polymorphisms rs792/(GHI), rs7956547(IGFI), rs3761243(GNRH2), rs11737764(FGF2), rs6599400(FGFR3), and rs1690916(MDM2) associations with bone tumors. In our work we've detected significant associations with some single nucleotide polymorphisms: IGFl.rs7956547, GNRH2.rs3761243 and FGFR3.rs6599400 in patients with malignant and borderline bone tumors.

Subjects :: Adolescent
Adult
Bone Neoplasms diagnosis
Case-Control Studies
Female
Genetic Association Studies
Gonadotropin-Releasing Hormone genetics
Humans
Insulin-Like Growth Factor I genetics
Male
Middle Aged
Neoplasms, Bone Tissue diagnosis
Receptor, Fibroblast Growth Factor, Type 3 genetics
Bone Neoplasms genetics
Neoplasms, Bone Tissue genetics
Polymorphism, Single Nucleotide

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