Accelerated radiotherapy for T1 to T2 glottic cancer.

Authors :: Motegi A
Kawashima M
Arahira S
Zenda S
Toshima M
Onozawa M
Hayashi R
Akimoto T
Source :: Head & neck [Head Neck] 2015 Apr; Vol. 37 (4), pp. 579-84. Date of Electronic Publication: 2014 Apr 10.
Publication Year :: 2015
Abstract: Background: Accelerated fractionation radiotherapy (RT) was administered in an attempt to improve the local control rates in patients with T1/T2 N0 glottic cancer.<br />Methods: Medical charts of 148 consecutive patients who had undergone RT using 2.4 Gray (Gy) once-daily fractionation between July 1999 and April 2007 were reviewed.<br />Results: Of 104 patients with T1 disease treated by RT, 82 received 60 Gy/25 fractions, and the remaining 22 with large tumor volumes and/or slow response to RT received 64.8 Gy/27 fractions. All 44 patients with T2 disease received 64.8 Gy/27 fractions. The 5-year local control and overall survival (OS) rates were 93% and 96%, respectively, in patients with T1 disease, and 77% and 91%, respectively, in patients with T2 disease. No severe acute toxicities were observed, although 2 patients (1%) developed severe late toxicity.<br />Conclusion: Accelerated RT for early glottic cancer is feasible, with encouraging local control rates.<br /> (© 2014 Wiley Periodicals, Inc.)