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Transmission of Onchocerca volvulus by Simulium neavei in Mount Elgon focus of Eastern Uganda has been interrupted.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2014 Jun; Vol. 90 (6), pp. 1159-66. Date of Electronic Publication: 2014 Mar 31. - Publication Year :
- 2014
-
Abstract
- The study determined that Simulium neavei-transmitted onchocerciasis in Mount Elgon onchocerciasis focus had been interrupted. Annual mass treatment with ivermectin changed to two times per year along with vector elimination in 2007. Then, baseline microfilaria (mf) prevalence data of 1994 in five sentinel communities were compared with follow-up data in 2005 and 2011. Blood spots from 3,051 children obtained in 2009 were analyzed for Onchocerca volvulus immunoglobulin G4 antibodies. Fresh water crab host captures and blackflies collected indicated their infestation with larval stages of S. neavei and presence or absence of the vector, respectively. Mf rates dropped from 62.2% to 0.5%, and 1 (0.03%) of 3,051 children was positive for O. volvulus antibodies. Crab infestation dropped from 41.9% in 2007 to 0%, and S. neavei biting reduced to zero. Both remained zero for the next 3 years, confirming interruption of onchocerciasis transmission, and interventions were halted.<br /> (© The American Society of Tropical Medicine and Hygiene.)
- Subjects :
- Adolescent
Animals
Antiparasitic Agents therapeutic use
Child
Child, Preschool
Humans
Infant
Ivermectin therapeutic use
Larva
Male
Microfilariae
Onchocerca volvulus immunology
Onchocerciasis drug therapy
Onchocerciasis prevention & control
Prevalence
Uganda epidemiology
Antibodies, Helminth blood
Brachyura parasitology
Insect Vectors parasitology
Onchocerca volvulus physiology
Onchocerciasis transmission
Simuliidae parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 90
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 24686740
- Full Text :
- https://doi.org/10.4269/ajtmh.13-0501