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Systemic therapy of hepatocellular carcinoma: current status and future perspectives.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Mar 28; Vol. 20 (12), pp. 3087-99. - Publication Year :
- 2014
-
Abstract
- The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades, the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of cancer-related deaths worldwide. Decision-making largely relies on evidence-based criteria, as showed in the US and European clinical practice guidelines, which endorse five therapeutic recommendations:resection; transplantation; radiofrequency ablation; chemoembolization; and sorafenib. Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patient's treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.
- Subjects :
- Angiogenesis Inhibitors therapeutic use
Animals
Antibodies, Monoclonal therapeutic use
Antineoplastic Agents therapeutic use
Clinical Trials as Topic
ErbB Receptors antagonists & inhibitors
Evidence-Based Medicine
Glypicans antagonists & inhibitors
Hormones therapeutic use
Humans
MAP Kinase Kinase Kinases antagonists & inhibitors
Medical Oncology trends
Molecular Targeted Therapy methods
Niacinamide analogs & derivatives
Niacinamide therapeutic use
Phenylurea Compounds therapeutic use
Protein Kinase Inhibitors chemistry
Sorafenib
TOR Serine-Threonine Kinases metabolism
Treatment Outcome
Carcinoma, Hepatocellular therapy
Liver Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 24696596
- Full Text :
- https://doi.org/10.3748/wjg.v20.i12.3087