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Oral (Gavage) Combined Developmental and Perinatal/Postnatal Reproduction Toxicity Study of Ammonium Salt of Perfluorinated Hexanoic Acid in Mice.
- Source :
-
International journal of toxicology [Int J Toxicol] 2014 May; Vol. 33 (3), pp. 219-237. Date of Electronic Publication: 2014 Apr 03. - Publication Year :
- 2014
-
Abstract
- The reproductive toxicity potential of Ammonium Salt of Perfluorinated Hexanoic Acid (PFHxA Ammonium Salt) in pregnant Crl: CD1(ICR) mice was investigated. Twenty females/group were administered the test substance or vehicle once daily from gestation day 6 through 18. Phase 1 doses: 0, 100, 350, and 500 mg/kg/d; phase 2: 0, 7, 35, and 175 mg/kg/d. Parameters evaluated include mortality, viability, body weights, clinical signs, abortions, premature deliveries, pregnancy and fertility, litter observations, maternal behavior, and sexual maturity in the F1 generation. The level of PFHxA Ammonium Salt was measured in the liver of F0 and F1 mice. At doses of 350 and 500 mg/kg/d maternal mortalities, excess salivation and changes in body weight gains occurred. Pup body weights were reduced on postpartum day (PPD) 0 in all the dosage groups, but persisted only in the 350 and 500 mg/kg/d groups. Additional effects at 300 and 500 mg/kg/d included stillbirths, reductions in viability indices, and delays in physical development. Levels of PFHxA Ammonium Salt in the livers of the 100 mg/kg/d dams were all below the lower limit of quantization (0.02 µg/mL); in the 350 mg/kg/d group, 3 of the 8 samples had quantifiable analytical results. In phase 2 no PFHxA Ammonium Salt was found in the liver. Adverse effects occurred only in the 175 mg/kg/d group and consisted of increased stillborn pups, pups dying on PPD 1, and reduced pup weights on PPD 1. Based on these data, the maternal and reproductive no observable adverse effect level of PFHxA Ammonium Salt is 100 mg/kg/d.<br /> (© The Author(s) 2014.)
- Subjects :
- Administration, Oral
Ammonium Chloride administration & dosage
Ammonium Chloride chemistry
Ammonium Chloride metabolism
Ammonium Chloride toxicity
Animals
Caproates administration & dosage
Caproates chemistry
Caproates metabolism
Dose-Response Relationship, Drug
Environmental Pollutants administration & dosage
Environmental Pollutants chemistry
Environmental Pollutants metabolism
Female
Fluorocarbons administration & dosage
Fluorocarbons chemistry
Fluorocarbons metabolism
Infertility, Female metabolism
Infertility, Female pathology
Infertility, Male metabolism
Infertility, Male pathology
Lactation
Male
Mice
No-Observed-Adverse-Effect Level
Pregnancy
Pregnancy Complications chemically induced
Pregnancy Complications metabolism
Pregnancy Complications pathology
Sexual Maturation drug effects
Tissue Distribution
Toxicokinetics
Weight Gain drug effects
Caproates toxicity
Environmental Pollutants toxicity
Fetal Development drug effects
Fluorocarbons toxicity
Infertility, Female chemically induced
Infertility, Male chemically induced
Maternal Exposure adverse effects
Prenatal Exposure Delayed Effects
Subjects
Details
- Language :
- English
- ISSN :
- 1092-874X
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 24700568
- Full Text :
- https://doi.org/10.1177/1091581814529449