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Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial.
- Source :
-
The British journal of nutrition [Br J Nutr] 2014 Jul 14; Vol. 112 (1), pp. 99-111. Date of Electronic Publication: 2014 Apr 08. - Publication Year :
- 2014
-
Abstract
- Pre-eclampsia is a serious hypertensive condition of pregnancy associated with high maternal and fetal morbidity and mortality. Se intake or status has been linked to the occurrence of pre-eclampsia by our own work and that of others. We hypothesised that a small increase in the Se intake of UK pregnant women of inadequate Se status would protect against the risk of pre-eclampsia, as assessed by biomarkers of pre-eclampsia. In a double-blind, placebo-controlled, pilot trial, we randomised 230 primiparous pregnant women to Se (60 μg/d, as Se-enriched yeast) or placebo treatment from 12 to 14 weeks of gestation until delivery. Whole-blood Se concentration was measured at baseline and 35 weeks, and plasma selenoprotein P (SEPP1) concentration at 35 weeks. The primary outcome measure of the present study was serum soluble vascular endothelial growth factor receptor-1 (sFlt-1), an anti-angiogenic factor linked with the risk of pre-eclampsia. Other serum/plasma components related to the risk of pre-eclampsia were also measured. Between 12 and 35 weeks, whole-blood Se concentration increased significantly in the Se-treated group but decreased significantly in the placebo group. At 35 weeks, significantly higher concentrations of whole-blood Se and plasma SEPP1 were observed in the Se-treated group than in the placebo group. In line with our hypothesis, the concentration of sFlt-1 was significantly lower at 35 weeks in the Se-treated group than in the placebo group in participants in the lowest quartile of Se status at baseline (P= 0·039). None of the secondary outcome measures was significantly affected by treatment. The present finding that Se supplementation has the potential to reduce the risk of pre-eclampsia in pregnant women of low Se status needs to be validated in an adequately powered trial.
- Subjects :
- Adult
Biomarkers analysis
Biomarkers blood
Double-Blind Method
Female
Humans
Incidence
Nails chemistry
Nutritional Status
Pilot Projects
Pre-Eclampsia blood
Pre-Eclampsia epidemiology
Pre-Eclampsia etiology
Pregnancy
Pregnancy Trimester, First
Risk
Selenium analysis
Selenium blood
Selenium deficiency
United Kingdom epidemiology
Yeast, Dried chemistry
Dietary Supplements
Pre-Eclampsia prevention & control
Selenium therapeutic use
Selenoprotein P blood
Vascular Endothelial Growth Factor Receptor-1 blood
Yeast, Dried therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 112
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 24708917
- Full Text :
- https://doi.org/10.1017/S0007114514000531