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Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21.
- Source :
-
BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 325875. Date of Electronic Publication: 2014 Feb 27. - Publication Year :
- 2014
-
Abstract
- This research was performed to observe the effect of GTS-21 on Collagen Induced Arthritis (CIA). CIA model was used and after the onset of arthritis, the rats were divided into three groups based on their clinical symptoms score. Two groups were intraperitoneally (IP) injected daily with GTS-21 (1 mg/kg, 2.5 mg/kg) for a week, whereas phosphate buffered saline (PBS) was used for the control group. Cytokine titers, radiological, and histological examinations were performed at different time points after treatment with GTS-21. Compared with those of the control, the levels of TNF-α, IL-1, and IL-6 in the serum were significantly reduced after GTS-21 management. In addition, radiological results show that bone degradation was inhibited as well. Moreover, the hematoxylin and eosin (H&E) staining indicated that the histological score was significantly alleviated in the therapeutic group. Tartrate-resistant acid phosphatase (TRAP) stain-positive cells were also detected in the destruction of the articular cartilage, which was significantly reduced compared with the control group. This study provides the first evidence on the effect of GTS-21 as a potential treatment for RA.
- Subjects :
- Animals
Arthritis, Experimental blood
Arthritis, Experimental pathology
Benzylidene Compounds administration & dosage
Humans
Interleukin-1 blood
Interleukin-6 blood
Nicotinic Antagonists administration & dosage
Pyridines administration & dosage
Rats
Receptors, Nicotinic blood
Tumor Necrosis Factor-alpha blood
Arthritis, Experimental drug therapy
Receptors, Nicotinic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 24719855
- Full Text :
- https://doi.org/10.1155/2014/325875