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Advances in acetabular osteolysis: biomarkers, imaging, and pharmacologic management.
- Source :
-
Instructional course lectures [Instr Course Lect] 2014; Vol. 63, pp. 177-86. - Publication Year :
- 2014
-
Abstract
- Acetabular osteolysis can be difficult to diagnose because patients often have no clinical symptoms even when there is substantial bone loss. Ideally, early detection would lead to early interventions. Imaging continues to be the frontline modality for the early detection of acetabular osteolysis. Although plain radiography is the current imaging modality most commonly used in routine follow-up examinations, its low sensitivity limits its usefulness. CT and MRI have proven to be better imaging modalities for the early detection of osteolysis; however, their use is limited by cost, radiation exposure, and time. Biomarkers hold promise for the early detection of osteolysis; however, their efficacy requires more rigorous research for validation. Early diagnosis and treatment of osteolysis may lead to better outcomes for patients.
- Subjects :
- Biomarkers metabolism
Bone Density Conservation Agents therapeutic use
Hip Prosthesis adverse effects
Humans
Osteolysis etiology
Prosthesis Failure
Acetabulum
Arthroplasty, Replacement, Hip adverse effects
Arthroplasty, Replacement, Hip instrumentation
Osteolysis diagnosis
Osteolysis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0065-6895
- Volume :
- 63
- Database :
- MEDLINE
- Journal :
- Instructional course lectures
- Publication Type :
- Academic Journal
- Accession number :
- 24720304