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Advances in acetabular osteolysis: biomarkers, imaging, and pharmacologic management.

Authors :
Illingworth KD
Wachter N
Maloney WJ
Paprosky WG
Ries MD
Saleh KJ
Source :
Instructional course lectures [Instr Course Lect] 2014; Vol. 63, pp. 177-86.
Publication Year :
2014

Abstract

Acetabular osteolysis can be difficult to diagnose because patients often have no clinical symptoms even when there is substantial bone loss. Ideally, early detection would lead to early interventions. Imaging continues to be the frontline modality for the early detection of acetabular osteolysis. Although plain radiography is the current imaging modality most commonly used in routine follow-up examinations, its low sensitivity limits its usefulness. CT and MRI have proven to be better imaging modalities for the early detection of osteolysis; however, their use is limited by cost, radiation exposure, and time. Biomarkers hold promise for the early detection of osteolysis; however, their efficacy requires more rigorous research for validation. Early diagnosis and treatment of osteolysis may lead to better outcomes for patients.

Details

Language :
English
ISSN :
0065-6895
Volume :
63
Database :
MEDLINE
Journal :
Instructional course lectures
Publication Type :
Academic Journal
Accession number :
24720304