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The pattern of cytokine production in vitro induced by ancient and modern Beijing Mycobacterium tuberculosis strains.
- Source :
-
PloS one [PLoS One] 2014 Apr 11; Vol. 9 (4), pp. e94296. Date of Electronic Publication: 2014 Apr 11 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- It is unclear to what extent the host-responses elicited by Beijing versus non-Beijing strains of Mycobacterium tuberculosis (MTB) contribute to the predominance of modern Beijing strains in Taiwan and some other Asian countries. The purpose of this study was to compare the expression profiles of virulence-related genes in human monocyte-derived macrophages infected in vitro with Beijing (ancient and modern strains) and non-Beijing strains (EAI strains) of MTB that are epidemic in Taiwan. We found that modern Beijing strains induced lower levels of pro-inflammatory cytokines, whereas EAI strains induced higher levels. Notably, the most prevalent modern Beijing sub-lineage, possessing intact RD150 and RD142 chromosomal regions, induced very low levels of pro-inflammatory cytokines, especially interleukin-1β. Moreover, in an intracellular growth assay, the survival of the same modern Beijing strain in human monocyte-derived macrophages was significantly higher than that of an ancient Beijing strain and an EAI strain. Taken together, these results may explain why modern Beijing strains of MTB predominate in Taiwan.
- Subjects :
- Bacterial Typing Techniques
Chemokines biosynthesis
Cluster Analysis
Epidemiological Monitoring
Humans
Inflammation Mediators metabolism
Macrophages microbiology
Macrophages pathology
Male
Monocytes pathology
Mycobacterium tuberculosis classification
Mycobacterium tuberculosis growth & development
Phylogeny
Taiwan epidemiology
Tuberculosis epidemiology
Tuberculosis microbiology
Cytokines biosynthesis
Mycobacterium tuberculosis physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24728339
- Full Text :
- https://doi.org/10.1371/journal.pone.0094296