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Visible-light-induced formal [3+2] cycloaddition for pyrrole synthesis under metal-free conditions.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 May 26; Vol. 53 (22), pp. 5653-6. Date of Electronic Publication: 2014 Apr 11. - Publication Year :
- 2014
-
Abstract
- A photocatalytic formal [3+2] cycloaddition of 2H-azirines with alkynes has been achieved under irradiation by visible light in the presence of organic dye photocatalysts. This transformation provides efficient access to highly functionalized pyrroles in good yields and has been applied to the synthesis of drug analogues. A primary trial of photocascade catalysis merging energy transfer and redox neutral reactions was shown to be successful.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Alkynes chemistry
Azirines chemistry
Catalysis
Coloring Agents chemistry
Cycloaddition Reaction
Energy Transfer
Hydroxymethylglutaryl-CoA Reductase Inhibitors chemical synthesis
Hydroxymethylglutaryl-CoA Reductase Inhibitors chemistry
Metals chemistry
Oxidation-Reduction
Light
Pyrroles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 53
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 24729379
- Full Text :
- https://doi.org/10.1002/anie.201400602