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Secondary prevention of epidemic gastric cancer in the model of Helicobacter pylori-associated gastritis.
- Source :
-
Digestive diseases (Basel, Switzerland) [Dig Dis] 2014; Vol. 32 (3), pp. 265-74. Date of Electronic Publication: 2014 Apr 10. - Publication Year :
- 2014
-
Abstract
- Irrespective of its etiology, long-standing, non-self-limiting gastric inflammation (mostly in Helicobacter pylori-associated cases) is the cancerization ground on which epidemic (intestinal-type) gastric carcinoma (GC) can develop. The natural history of invasive gastric adenocarcinoma encompasses gastritis, atrophic mucosal changes, and intraepithelial neoplasia (IEN). The topography, the extent and the severity of the atrophic changes significantly correlate with the risk of developing both IEN and GC. In recent years, both noninvasive (serological) tests and invasive (endoscopy/biopsy) procedures have been proposed to stratify patients according to different classes of GC risk. As a consequence, different patient-tailored GC secondary prevention strategies have been put forward. This review summarizes the histological features of H. pylori-related gastritis and the natural history of the disease. Histological and serological strategies to assess GC risk as well as the clinical management of atrophic gastritis patients are also discussed.<br /> (© 2014 S. Karger AG, Basel.)
- Subjects :
- Carcinogenesis pathology
Gastritis blood
Gastritis complications
Gastritis pathology
Humans
Stomach Neoplasms blood
Stomach Neoplasms pathology
Stomach Neoplasms prevention & control
Gastritis microbiology
Helicobacter pylori physiology
Models, Biological
Secondary Prevention
Stomach Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9875
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Digestive diseases (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 24732192
- Full Text :
- https://doi.org/10.1159/000357857