Back to Search
Start Over
Peramivir and laninamivir susceptibility of circulating influenza A and B viruses.
- Source :
-
Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2014 Mar; Vol. 8 (2), pp. 135-9. - Publication Year :
- 2014
-
Abstract
- Influenza viruses collected from regions of Asia, Africa and Oceania between 2009 and 2012 were tested for their susceptibility to two new neuraminidase inhibitors, peramivir and laninamivir. All viruses tested had normal laninamivir inhibition. However, 3·2% (19/599) of A(H1N1)pdm09 viruses had highly reduced peramivir inhibition (due to H275Y NA mutation) and <1% (6/1238) of influenza B viruses had reduced or highly reduced peramivir inhibition, with single occurrence of variants containing I221T, A245T, K360E, A395E, D432G and a combined G145R+Y142H mutation. These data demonstrate that despite an increase in H275Y variants in 2011, there was no marked change in the frequency of peramivir- or laninamivir-resistant variants following the market release of the drugs in Japan in 2010.
- Subjects :
- Acids, Carbocyclic
Africa
Asia
Humans
Influenza A virus isolation & purification
Influenza B virus isolation & purification
Influenza, Human virology
Japan
Microbial Sensitivity Tests
Mutation, Missense
Neuraminidase antagonists & inhibitors
Neuraminidase genetics
Oceania
Pyrans
Sialic Acids
Viral Proteins antagonists & inhibitors
Viral Proteins genetics
Zanamivir pharmacology
Antiviral Agents pharmacology
Cyclopentanes pharmacology
Guanidines pharmacology
Influenza A virus drug effects
Influenza B virus drug effects
Zanamivir analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1750-2659
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Influenza and other respiratory viruses
- Publication Type :
- Academic Journal
- Accession number :
- 24734292
- Full Text :
- https://doi.org/10.1111/irv.12187