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Soy lipophilic protein nanoparticles as a novel delivery vehicle for conjugated linoleic acid.

Authors :
Gao ZM
Zhu LP
Yang XQ
He XT
Wang JM
Guo J
Qi JR
Wang LJ
Yin SW
Source :
Food & function [Food Funct] 2014 Jun; Vol. 5 (6), pp. 1286-93. Date of Electronic Publication: 2014 Apr 17.
Publication Year :
2014

Abstract

Soy lipophilic protein nanoparticles (LPP), which present a novel delivery vehicle for conjugated linoleic acid (CLA), were fabricated by ultrasonication of the soy lipophilic protein (LP), which exhibits unique characteristics including a high loading capacity, oxidation protection and a sustained releasing profile in vitro for CLA. The CLA-loaded LPP exhibited a mean diameter of 170 ± 0.63 nm and a loading capacity of 26.3 ± 0.40% (w/w). A coating of sodium caseinate (SC) on the surface improved the colloidal stability of the CLA-loaded LPP. This encapsulation conferred protection against the oxidation of CLA, by which the head space-oxygen consumption and hydrogen peroxide value were obviously decreased in comparison with the SC-encapsulated CLA and CLA alone. The delivery system enables a sustained releasing profile of CLA in a simulated gastrointestinal tract (GIT). These findings illustrate that the LPP could act as an effective delivery device for CLA, which could provide oxidation stability and a sustained release property.

Details

Language :
English
ISSN :
2042-650X
Volume :
5
Issue :
6
Database :
MEDLINE
Journal :
Food & function
Publication Type :
Academic Journal
Accession number :
24741678
Full Text :
https://doi.org/10.1039/c3fo60497g