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Capsaicin-induced neurogenic inflammation in pig skin: a behavioural study.
- Source :
-
Research in veterinary science [Res Vet Sci] 2014 Jun; Vol. 96 (3), pp. 447-53. Date of Electronic Publication: 2014 Apr 02. - Publication Year :
- 2014
-
Abstract
- Topical capsaicin is a well-established model of experimental hyperalgesia. Its application to the study of animals has been limited to few species. The effect of topical capsaicin on hyperalgesia in porcine skin was evaluated as part of a study of inflammatory pain in the pig. Two experiments were carried out on pigs of 27 ± 5 kg (n = 8) and 57 ± 3 kg (n = 16). Thermal and mechanical noxious stimuli were provided (CO2 laser and Pressure Application Measurement device) to assess avoidance behaviours. Capsaicin induced significant thermal hyperalgesia in the smaller pigs (P < 0.05), while no mechanical hyperalgesia was observed in either animal group. The present model of topical capsaicin application may be useful to investigate the mechanisms of primary hyperalgesia in this species, although some experimental conditions, such as the administration route and cutaneous morphology, need to be evaluated.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Behavior, Animal drug effects
Capsaicin administration & dosage
Hyperalgesia chemically induced
Male
Neurogenic Inflammation chemically induced
Random Allocation
Statistics, Nonparametric
Swine psychology
Video Recording
Capsaicin pharmacology
Hyperalgesia veterinary
Neurogenic Inflammation veterinary
Skin immunology
Swine immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2661
- Volume :
- 96
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Research in veterinary science
- Publication Type :
- Academic Journal
- Accession number :
- 24746289
- Full Text :
- https://doi.org/10.1016/j.rvsc.2014.03.023