Back to Search Start Over

Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease.

Authors :
Ding Y
Spund B
Glazman S
Shrier EM
Miri S
Selesnick I
Bodis-Wollner I
Source :
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2014 Nov; Vol. 121 (11), pp. 1367-76. Date of Electronic Publication: 2014 Apr 20.
Publication Year :
2014

Abstract

Spectral-domain Optical coherence tomography (OCT) has shown remarkable utility in the study of retinal disease and has helped to characterize the fovea in Parkinson disease (PD) patients. We developed a detailed mathematical model based on raw OCT data to allow differentiation of foveae of PD patients from healthy controls. Of the various models we tested, a difference of a Gaussian and a polynomial was found to have "the best fit". Decision was based on mathematical evaluation of the fit of the model to the data of 45 control eyes versus 50 PD eyes. We compared the model parameters in the two groups using receiver-operating characteristics (ROC). A single parameter discriminated 70 % of PD eyes from controls, while using seven of the eight parameters of the model allowed 76 % to be discriminated. The future clinical utility of mathematical modeling in study of diffuse neurodegenerative conditions that also affect the fovea is discussed.

Details

Language :
English
ISSN :
1435-1463
Volume :
121
Issue :
11
Database :
MEDLINE
Journal :
Journal of neural transmission (Vienna, Austria : 1996)
Publication Type :
Academic Journal
Accession number :
24748549
Full Text :
https://doi.org/10.1007/s00702-014-1214-2