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Occult hepatitis B virus infection predicts de novo hepatitis B infection in patients with alcoholic cirrhosis after liver transplantation.
- Source :
-
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2015 Mar; Vol. 35 (3), pp. 897-904. Date of Electronic Publication: 2014 May 12. - Publication Year :
- 2015
-
Abstract
- Background & Aims: Occult hepatitis B virus infection (OBI) in patients undergoing liver transplantation (LT) is a suspected source of de novo hepatitis B virus (HBV) infection after LT. This study aimed to investigate the prevalence of OBI in liver transplant recipients with alcoholic cirrhosis and demonstrate the association between OBI and de novo HBV infection after LT in these patients.<br />Methods: Forty-three patients with alcoholic cirrhosis who were negative for HBsAg before LT were recruited in this retrospective study. DNA was extracted from paraffin-embedded native liver tissues and quantified for HBV DNA by real-time PCR. Correlation between de novo HBV infection after LT (positive HBsAg and/or detectable HBV DNA in serum) and detection of intrahepatic HBV DNA before LT was analysed.<br />Results: Detectable HBV DNA in the explanted liver was found in 41.9% (18/43) of the patients and was thus defined as OBI, which was correlated with the presence of serum hepatitis B core antibody (P = 0.008). De novo HBV infection occurred in 18.6% (8/43) of the recipients at a median of 10 months after LT. The rate of de novo HBV infection was 38.9% (7/18) in patients with OBI, compared with 4% (1/25) in patients without OBI (P = 0.004). Furthermore, de novo HBV infection was inversely correlated with the presence of hepatitis B surface antibody in recipients with OBI (P = 0.026).<br />Conclusion: With a prevalence of 41.9% in liver transplant recipients with alcoholic cirrhosis, OBI in the native liver can predict de novo HBV infection after LT.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
China epidemiology
End Stage Liver Disease surgery
Female
Hepatitis B epidemiology
Humans
Liver Cirrhosis, Alcoholic surgery
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
End Stage Liver Disease virology
Hepatitis B complications
Liver Cirrhosis, Alcoholic virology
Liver Transplantation
Postoperative Complications virology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-3231
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Liver international : official journal of the International Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 24750566
- Full Text :
- https://doi.org/10.1111/liv.12567