NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis.

Authors :: Agúndez JA
García-Martín E
Martínez C
Benito-León J
Millán-Pascual J
Calleja P
Díaz-Sánchez M
Pisa D
Turpín-Fenoll L
Alonso-Navarro H
Ayuso-Peralta L
Torrecillas D
Plaza-Nieto JF
Jiménez-Jiménez FJ
Source :: BMC neurology [BMC Neurol] 2014 Apr 23; Vol. 14, pp. 87. Date of Electronic Publication: 2014 Apr 23.
Publication Year :: 2014
Abstract: Background: A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population.<br />Methods: We analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays.<br />Results: NQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS.<br />Conclusions: Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk.