Back to Search
Start Over
Further serological and RFLP analysis of the MRL-+/+ and MRL-lpr/lpr mice.
- Source :
-
Journal of immunogenetics [J Immunogenet] 1988 Oct-Dec; Vol. 15 (5-6), pp. 307-19. - Publication Year :
- 1988
-
Abstract
- During their ageing, MRL-lpr/lpr mice (H-2k) suffer from progressive lymph node enlargement, associated with the development of several acute autoimmune lesions. The primary effect and location of the lpr mutation is unknown. However, a minority of the lymphoid cells of some MRL-+/+, as well as MRL-lpr/lpr mice, express 'alien' H-2d antigenic specificities. In the course of the investigation of the origin of the latter, we have carried out the genotyping of the MHC of several MRL-+/+ and MRL-lpr/lpr mice using the Southern blotting technique and employing a variety of MHC class I and class II probes, and restriction enzymes known to discriminate between the d and the k haplotypes. None of the results obtained so far suggests the contribution of genuine H-2d genes to the MHC of the MRL-+/+ and MRL-lpr/lpr mouse strains. Alternative hypotheses for the generation of the 'alien' epitopes are discussed.
- Subjects :
- Animals
Autoimmune Diseases genetics
Autoimmune Diseases immunology
Epitopes genetics
Genes, MHC Class I
Genes, MHC Class II
Genotype
H-2 Antigens genetics
Mice
Mice, Mutant Strains genetics
Polymorphism, Restriction Fragment Length
Major Histocompatibility Complex
Mice, Mutant Strains immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0305-1811
- Volume :
- 15
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Journal of immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 2475545
- Full Text :
- https://doi.org/10.1111/j.1744-313x.1988.tb00434.x