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Irradiation Toxicity and Inflammatory Bowel Diseases (IBD): Review.
- Source :
-
Reviews on recent clinical trials [Rev Recent Clin Trials] 2014; Vol. 9 (1), pp. 31-6. - Publication Year :
- 2014
-
Abstract
- Background/aim: The evaluation of radiotherapy toxicity in oncologic IBD patients. Defining the optimal patient and treatment factors that would be able to reduce the risk to organs.<br />Materials and Methods: A review of all published radiotherapy trials was performed to identify the clinical and treatment factors of inflammatory bowel disease's patients treated for different solid tumors.<br />Results: Overall, acute (Grade ≥ 3) gastrointestinal complications attributable to RT ranged between 20-21% of the treated patients. A late Grade ≥ 3 gastrointestinal toxicity was developed in a range between 8-29%.<br />Conclusion: A special attention should be given to the description of IBD location, activity status, concurrent chemotherapy, irradiation dose and technique, in order to minimize post-irradiation morbidity. It is not easy to distinguish late morbidity attributable to radiotherapy due to the IBD itself.
Details
- Language :
- English
- ISSN :
- 1876-1038
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Reviews on recent clinical trials
- Publication Type :
- Academic Journal
- Accession number :
- 24758537
- Full Text :
- https://doi.org/10.2174/1574887109666140423123845