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Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.
- Source :
-
Science (New York, N.Y.) [Science] 1989 Aug 18; Vol. 245 (4919), pp. 752-5. - Publication Year :
- 1989
-
Abstract
- Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript was present in stromal cells derived from epithelial tissues. By comparison with the expression of other epithelial cell mitogens, only KGF, among known human growth factors, has the properties of a stromal mediator of epithelial cell proliferation.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Cell Division
Codon
DNA genetics
DNA isolation & purification
Epithelial Cells
Epithelium analysis
Epithelium metabolism
Fibroblast Growth Factor 10
Fibroblast Growth Factor 7
Fibroblasts metabolism
Gene Expression Regulation
Growth Substances physiology
Humans
Mesoderm metabolism
Mice
Molecular Sequence Data
Nucleic Acid Hybridization
Oligonucleotide Probes
RNA analysis
Sequence Homology, Nucleic Acid
Skin analysis
Tissue Distribution
Transcription, Genetic
Fibroblast Growth Factors genetics
Growth Substances genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 245
- Issue :
- 4919
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 2475908
- Full Text :
- https://doi.org/10.1126/science.2475908