Participation of PI3K, MAPK ERK1/2, and p38 in the realization of growth potential of mesenchymal precursor cells under in vitro conditions.

Authors :: Zyuz'kov GN
Danilets MG
Ligacheva AA
Zhdanov VV
Udut EV
Miroshnichenko LA
Simanina EV
Trofimova ES
Minakova MY
Chaikovskii AV
Agafonov VI
Dygai AM
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2014 Feb; Vol. 156 (4), pp. 556-9. Date of Electronic Publication: 2014 Mar 05.
Publication Year :: 2014
Abstract: We studied the role of intracellular signal molecules PI3K, MAPK ERK1/2, and p38 in the realization of the growth potential of mesenchymal progenitor elements. Under in vitro conditions, PI3K и ERK1/2 specifi c inhibitors reduced fi broblastic colony- and cluster-formation and considerably suppressed proliferative activity of mesenchymal precursors. Blocker of p38 and protein kinase B had no effect on the function of fi broblast CFU.

Subjects :: Animals
Cell Culture Techniques
Cell Proliferation
Cells, Cultured
Chromones pharmacology
Extracellular Signal-Regulated MAP Kinases antagonists & inhibitors
MAP Kinase Signaling System
Mesenchymal Stem Cells drug effects
Mice, Inbred C57BL
Morpholines pharmacology
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors pharmacology
p38 Mitogen-Activated Protein Kinases antagonists & inhibitors
Extracellular Signal-Regulated MAP Kinases metabolism
Mesenchymal Stem Cells physiology
Phosphatidylinositol 3-Kinases metabolism
p38 Mitogen-Activated Protein Kinases metabolism

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