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Vitamin A and risk of bladder cancer: a meta-analysis of epidemiological studies.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2014 Apr 29; Vol. 12, pp. 130. Date of Electronic Publication: 2014 Apr 29. - Publication Year :
- 2014
-
Abstract
- Background: Epidemiological studies have reported the preventive effect of vitamin A intake on bladder cancer. However, the findings are inconsistent. To address this issue we conducted a meta-analysis to investigate the quantitative effects of vitamin A on bladder cancer.<br />Methods: We searched MEDLINE and Embase databases and the references of the relevant articles in English to include studies on dietary or blood vitamin A for the risk of bladder cancer. We performed a meta-analysis using both fixed-effects and random-effects models.<br />Results: Twenty-five articles on dietary vitamin A or blood vitamin A were included according to the eligibility criteria. The pooled risk estimates of bladder cancer were 0.82 (95% CI 0.65, 0.95) for total vitamin A intake, 0.88 (95% CI 0.73, 1.02) for retinol intake, and 0.64 (95% CI 0.38, 0.90) for blood retinol levels. We also found inverse associations between subtypes of carotenoids and bladder cancer risk.<br />Conclusion: The findings of this meta-analysis indicate that high vitamin A intake was associated with a lower risk of bladder cancer. Larger studies with prospective design and rigorous methodology should be considered to validate the current findings.
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24773914
- Full Text :
- https://doi.org/10.1186/1477-7819-12-130