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TWIST overexpression predicts biochemical recurrence-free survival in prostate cancer patients treated with radical prostatectomy.
- Source :
-
Scandinavian journal of urology [Scand J Urol] 2015 Feb; Vol. 49 (1), pp. 51-7. Date of Electronic Publication: 2014 Apr 30. - Publication Year :
- 2015
-
Abstract
- Objective: The aim of this study was to determine whether TWIST and androgen receptor (AR) expression can predict the outcome in radical prostatectomy (RP) patients.<br />Material and Methods: Samples from different tumour areas of 181 prostate cancer patients were analysed for TWIST and AR expression, and the results were correlated with known clinicopathological data and biochemical recurrence-free survival (BFS).<br />Results: TWIST overexpression in the margin area of the tumour (M-TWIST) was related to positive surgical margin (p = 0.047), capsule invasion (p = 0.006) and biochemical recurrence (BCR) (p = 0.004). AR expression in the margin area of the tumour (M-AR) was associated with high Gleason score (p = 0.004), positive surgical margin (p = 0.004) and BCR (p = 0.05). M-TWIST overexpression was clearly associated with M-AR expression (p < 0.0001). Four parameters, i.e. M-TWIST overexpression (p < 0.0001), positive surgical margin (p = 0.003), high Gleason score (p < 0.0001) and M-AR expression (p = 0.008), predicted BFS. In the multivariate analysis, M-TWIST overexpression (p = 0.011) and Gleason score (p = 0.002) were the only independent predictors of BFS.<br />Conclusions: M-TWIST overexpression is associated with clinicopathological prognosis factors and M-AR overexpression and is a powerful independent predictor of BFS in conjunction with the Gleason score in prostate cancer patients treated with RP.
- Subjects :
- Aged
Cohort Studies
Disease-Free Survival
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Grading
Neoplasm, Residual
Prognosis
Prostate-Specific Antigen blood
Prostatectomy
Prostatic Neoplasms pathology
Prostatic Neoplasms surgery
Retrospective Studies
Neoplasm Recurrence, Local metabolism
Nuclear Proteins metabolism
Prostatic Neoplasms metabolism
Receptors, Androgen metabolism
Twist-Related Protein 1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2168-1813
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 24779451
- Full Text :
- https://doi.org/10.3109/21681805.2014.909529