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Connecting the nucleolus to the cell cycle and human disease.
- Source :
-
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2014 Aug; Vol. 28 (8), pp. 3290-6. Date of Electronic Publication: 2014 Apr 30. - Publication Year :
- 2014
-
Abstract
- Long known as the center of ribosome synthesis, the nucleolus is connected to cell cycle regulation in more subtle ways. One is a surveillance system that reacts promptly when rRNA synthesis or processing is impaired, halting cell cycle progression. Conversely, the nucleolus also acts as a first-responder to growth-related stress signals. Here we review emerging concepts on how these "infraribosomal" links between the nucleolus and cell cycle progression operate in both forward and reverse gears. We offer perspectives on how new cancer therapeutic designs that target this infraribosomal mode of cell growth control may shape future clinical progress.<br /> (© FASEB.)
- Subjects :
- Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
DNA Repair
Forecasting
Gene Expression Regulation drug effects
Gene Expression Regulation physiology
Genetic Diseases, Inborn genetics
Genetic Diseases, Inborn metabolism
Humans
Molecular Targeted Therapy
Neoplasms drug therapy
Neoplasms genetics
Neoplasms metabolism
Nuclear Proteins physiology
Pol1 Transcription Initiation Complex Proteins physiology
RNA, Ribosomal biosynthesis
Ribosomal Proteins deficiency
Ribosomal Proteins genetics
Ribosomal Proteins physiology
Signal Transduction physiology
Cell Cycle physiology
Cell Nucleolus physiology
Models, Biological
Ribosomes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6860
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 24790035
- Full Text :
- https://doi.org/10.1096/fj.14-254680