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Long-term viremia and fecal shedding in pups after modified-live canine parvovirus vaccination.
- Source :
-
Vaccine [Vaccine] 2014 Jun 24; Vol. 32 (30), pp. 3850-3. Date of Electronic Publication: 2014 Apr 30. - Publication Year :
- 2014
-
Abstract
- Canine parvovirus (CPV) modified live virus vaccines are able to infect vaccinated dogs replicating in the bloodstream and enteric mucosa. However, the exact duration and extent of CPV vaccine-induced viremia and fecal shedding are not known. With the aim to fill this gap, 26 dogs were administered two commercial vaccines containing a CPV-2 or CPV-2b strain and monitored for 28 days after vaccination. By using real-time PCR, vaccine-induced viremia and shedding were found to be long lasting for both vaccinal strains. Vaccinal CPV-2b shedding was detected for a shorter period than CPV-2 (12 against 19 mean days) but with greater viral loads, whereas viremia occurred for a longer period (22 against 19 mean days) and with higher titers for CPV-2b. Seroconversion appeared as early as 7 and 14 days post-vaccination for CPV-2b and CPV-2 vaccines, respectively. With no vaccine there was any diagnostic interference using in-clinic or hemagglutination test, since positive results were obtained only by fecal real-time PCR testing. The present study adds new insights into the CPV vaccine persistence in the organism and possible interference with diagnostic tests.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antibodies, Viral blood
DNA, Viral isolation & purification
Dogs
Feces virology
Female
Hemagglutination Inhibition Tests
Male
Parvoviridae Infections prevention & control
Parvovirus, Canine
Vaccination veterinary
Vaccines, Attenuated administration & dosage
Viral Load
Dog Diseases prevention & control
Parvoviridae Infections veterinary
Viral Vaccines administration & dosage
Viremia diagnosis
Virus Shedding
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 32
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 24793948
- Full Text :
- https://doi.org/10.1016/j.vaccine.2014.04.050