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MTOR mutations in the crosshairs of targeted therapy.
- Source :
-
Cancer discovery [Cancer Discov] 2014 May; Vol. 4 (5), pp. 513-5. - Publication Year :
- 2014
-
Abstract
- The identification of genetic lesions that affect tumor sensitivity to targeted therapies is a major objective of precision medicine. Two reports in this issue combine tumor genome analyses with functional characterization to uncover activating mutations in MTOR that confer sensitivity to a clinically used mTOR inhibitor.<br /> (©2014 AACR.)
- Subjects :
- Drug Resistance, Neoplasm
Humans
Molecular Targeted Therapy methods
Mutation
Neoplasms genetics
TOR Serine-Threonine Kinases antagonists & inhibitors
TOR Serine-Threonine Kinases metabolism
Neoplasms drug therapy
Protein Kinase Inhibitors therapeutic use
TOR Serine-Threonine Kinases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2159-8290
- Volume :
- 4
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer discovery
- Publication Type :
- Academic Journal
- Accession number :
- 24795009
- Full Text :
- https://doi.org/10.1158/2159-8290.CD-14-0332