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Outcome of organs procured from donors on extracorporeal membrane oxygenation support: an analysis of kidney and liver allograft data.
- Source :
-
Clinical transplantation [Clin Transplant] 2014 Jul; Vol. 28 (7), pp. 816-20. Date of Electronic Publication: 2014 Jun 11. - Publication Year :
- 2014
-
Abstract
- Introduction: Extracorporeal membrane oxygenation has become rescue therapy for adults with overwhelming cardiac and/or respiratory failure. Not all patients are saved, creating a new cohort of potential organ donors. This study examines the outcomes of liver and kidney allografts procured from donors on extracorporeal membrane oxygenation (ECMO).<br />Methods: A retrospective review was conducted through the local organ procurement organization. Donors on ECMO prior to notification were classified into donation after brain death (DBD) and donation after cardiac death (DCD). We compared short-term outcome data against published standards.<br />Results: Between 1995 and 2012, 97 organs were procured from 41 donors supported on ECMO. There were 68 kidneys donated, 51 were transplanted and 17 discarded. Excluding extended criteria donors, 29 DBD and 13 DCD kidneys were transplanted from donors supported on ECMO. Delayed graft function occurred in 34% of DBD kidneys and 38% of DCD kidneys. Kidney allograft survival at one yr was 93%. Twenty-four livers were procured, nine discarded, and 15 transplanted. Ninety-three percent of liver transplant recipients were alive with graft function at one yr.<br />Conclusions: Donation after brain death kidneys procured from donors on ECMO perform similarly to non-ECMO organs with regard to delayed graft function (DGF), one-yr graft survival and function. Livers from ECMO donors have a higher discard rate than non-ECMO donors, but function similarly at six months and one yr.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Allografts
Child
Child, Preschool
Delayed Graft Function
Female
Follow-Up Studies
Graft Survival
Humans
Infant
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Young Adult
Brain Death
Extracorporeal Membrane Oxygenation
Kidney Transplantation
Liver Transplantation
Tissue Donors
Tissue and Organ Procurement statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 28
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 24805948
- Full Text :
- https://doi.org/10.1111/ctr.12384