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The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling.
- Source :
-
Metabolic brain disease [Metab Brain Dis] 2015 Feb; Vol. 30 (1), pp. 47-55. Date of Electronic Publication: 2014 May 08. - Publication Year :
- 2015
-
Abstract
- Irritable bowel syndrome (IBS) is induced by dysfunction of central nervous and peripheral intestinal systems, which affects an estimated 10-15% population worldwide annually. Stress-related psychiatric disorders including depression and anxiety are often comorbid with gastrointestinal function disorder, such as IBS. However, the mechanism of IBS still remains unknown. Curcumin is a biologically active phytochemical presents in turmeric and has pharmacological actions that benefit patients with depression and anxiety. Our study found that IBS rats showed depression- and anxiety-like behaviors associated with decreased 5-HT (serotonin), BDNF (Brain-derived neurotrophic factor) and pCREB (phosphorylation of cAMP response element-binding protein) expression in the hippocampus after chronic acute combining stress (CAS). However, these decreased parameters were obviously increased in the colonic after CAS. Curcumin (40 mg/kg) reduced the immobility time of forced swimming and the number of buried marbles in behavioral tests of CAS rats. Curcumin also decreased the number of fecal output and abdominal withdrawal reflex (AWR) scores in response to graded distention. Moreover, curcumin increased serotonin, BDNF and pCREB levels in the hippocampus, but they were decreased in the colonic of CAS rats. 5-HT(1A) receptor antagonist NAN-190 reversed the effects of curcumin on behaviors and the changes of intestine, pCREB and BDNF expression, which are related to IBS. These results suggested that curcumin exerts the effects on IBS through regulating neurotransmitters, BDNF and CREB signaling both in the brain and peripheral intestinal system.
- Subjects :
- Animals
Anxiety drug therapy
Anxiety physiopathology
Brain-Derived Neurotrophic Factor biosynthesis
Colon metabolism
Curcumin pharmacology
Cyclic AMP Response Element-Binding Protein biosynthesis
Defecation
Diazepam pharmacology
Disease Models, Animal
Drug Evaluation, Preclinical
Gastrointestinal Motility drug effects
Hippocampus metabolism
Imipramine pharmacology
Irritable Bowel Syndrome physiopathology
Male
Phosphorylation
Physical Exertion
Piperazines pharmacology
Pressure adverse effects
Protein Processing, Post-Translational
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT1A biosynthesis
Receptor, Serotonin, 5-HT1A drug effects
Receptor, Serotonin, 5-HT1A physiology
Serotonin biosynthesis
Serotonin 5-HT1 Receptor Antagonists pharmacology
Signal Transduction
Stress, Physiological physiology
Stress, Psychological physiopathology
Up-Regulation drug effects
Curcumin therapeutic use
Enteric Nervous System physiopathology
Hippocampus physiopathology
Irritable Bowel Syndrome drug therapy
Serotonin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7365
- Volume :
- 30
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Metabolic brain disease
- Publication Type :
- Academic Journal
- Accession number :
- 24807589
- Full Text :
- https://doi.org/10.1007/s11011-014-9554-z