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Inverse relationship between "a body shape index" (ABSI) and fat-free mass in women and men: Insights into mechanisms of sarcopenic obesity.
- Source :
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Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2015 Apr; Vol. 34 (2), pp. 323-7. Date of Electronic Publication: 2014 Apr 13. - Publication Year :
- 2015
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Abstract
- Background & Aims: Sarcopenic obesity may be defined by a high fat to fat-free mass (FM/FFM) ratio. Skeletal muscle may be negatively influenced by the pro-inflammatory milieu associated with visceral fat, while the loading effect induced by a heavier body mass index (BMI) may enhance muscle anabolism. Recently, a new anthropometric measure based on waist circumference (A Body Shape Index, ABSI) was developed. In this study we have assessed the predictive power of ABSI on the FFM index (FFMI), a surrogate marker of lean mass.<br />Methods: Standard anthropometric parameters and ABSI as well as body composition data (fat and fat-free mass determined by bioelectrical impedance analysis) were assessed in 111 female and 89 male overweight/obese subjects, with no clinically significant co-morbidities. Groups with higher- or lower-ABSI were identified according to median values of this index.<br />Results: In women and men, ABSI did not correlate with BMI, while multiple linear regression indicated that BMI (β-coefficients: 0.62 and 0.77, respectively) and ABSI (β-coefficients: -0.26 and -0.22, respectively) independently predicted FFMI (multiple R: 0.72 and 0.83, respectively, P < 0.001). Men and women with lower-ABSI exhibited significantly greater FFMI than the higher-ABSI groups for comparable values of BMI. In men, ABSI was correlated positively with C-reactive protein (CRP) (R = 0.30; P < 0.05) and negatively with the reciprocal of insulin (R = 0.28; P < 0.05), an index of insulin sensitivity. FM/FFM ratio significantly (P < 0.01) correlated with CRP (R = 0.31) in women only.<br />Conclusions: ABSI, a recently introduced marker of abdominal adiposity, may contribute to define the risk of sarcopenia in overweight/obese individuals.<br /> (Copyright © 2014. Published by Elsevier Ltd.)
- Subjects :
- Adult
Age Factors
Body Mass Index
C-Reactive Protein analysis
Electric Impedance
Female
Humans
Insulin Resistance
Male
Middle Aged
Obesity blood
Obesity diagnosis
Overweight blood
Overweight diagnosis
Predictive Value of Tests
Regression Analysis
Risk Factors
Sarcopenia blood
Sarcopenia diagnosis
Sex Factors
Adipose Tissue
Anthropometry methods
Body Composition
Obesity, Abdominal diagnosis
Waist Circumference
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1983
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical nutrition (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 24814384
- Full Text :
- https://doi.org/10.1016/j.clnu.2014.03.015