Back to Search Start Over

EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells.

Authors :
Jiang L
Lui YL
Li H
Chan CF
Lan R
Chan WL
Lau TC
Tsao GS
Mak NK
Wong KL
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2014 Jun 21; Vol. 50 (49), pp. 6517-9. Date of Electronic Publication: 2014 May 13.
Publication Year :
2014

Abstract

An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.

Details

Language :
English
ISSN :
1364-548X
Volume :
50
Issue :
49
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
24821080
Full Text :
https://doi.org/10.1039/c4cc01589d