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EBNA1-specific luminescent small molecules for the imaging and inhibition of latent EBV-infected tumor cells.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2014 Jun 21; Vol. 50 (49), pp. 6517-9. Date of Electronic Publication: 2014 May 13. - Publication Year :
- 2014
-
Abstract
- An EBNA1-specific small molecule (JLP2) has been synthesised. As a strong binder and dimerization inhibitor of EBNA1 in vitro, JLP2 may be used as a selective luminescent agent for the imaging and inhibition of latent EBV-infected cancer cells.
- Subjects :
- Binding Sites
Cell Survival drug effects
Dimerization
Epstein-Barr Virus Nuclear Antigens metabolism
HeLa Cells
Humans
Microscopy, Confocal
Molecular Docking Simulation
Protein Structure, Tertiary
Pyridinium Compounds metabolism
Pyridinium Compounds toxicity
Epstein-Barr Virus Nuclear Antigens chemistry
Herpesvirus 4, Human metabolism
Pyridinium Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 50
- Issue :
- 49
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 24821080
- Full Text :
- https://doi.org/10.1039/c4cc01589d