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Pseudogenes as competitive endogenous RNAs: target prediction and validation.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2014; Vol. 1167, pp. 199-212. - Publication Year :
- 2014
-
Abstract
- Pseudogenes may regulate expression of their parental genes as well as other protein-coding genes through various mechanisms. One such mechanism is the ability to act as competitive endogenous RNA (ceRNA) and participate in microRNA-mediated cross-regulation. Here, we outline how to predict the targets of pseudogene ceRNAs bioinformatically and how to validate them experimentally.
- Subjects :
- 3' Untranslated Regions
Gene Expression
Gene Silencing
Genes, Reporter
Humans
MicroRNAs genetics
RNA Interference
RNA, Messenger genetics
Reproducibility of Results
Ribonuclease III deficiency
Ribonuclease III genetics
Ribonuclease III metabolism
Computational Biology methods
Genomics methods
Pseudogenes genetics
RNA genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1940-6029
- Volume :
- 1167
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 24823779
- Full Text :
- https://doi.org/10.1007/978-1-4939-0835-6_13