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Echinochrome A protects mitochondrial function in cardiomyocytes against cardiotoxic drugs.
- Source :
-
Marine drugs [Mar Drugs] 2014 May 13; Vol. 12 (5), pp. 2922-36. Date of Electronic Publication: 2014 May 13. - Publication Year :
- 2014
-
Abstract
- Echinochrome A (Ech A) is a naphthoquinoid pigment from sea urchins that possesses antioxidant, antimicrobial, anti-inflammatory and chelating abilities. Although Ech A is the active substance in the ophthalmic and cardiac drug Histochrome®, its underlying cardioprotective mechanisms are not well understood. In this study, we investigated the protective role of Ech A against toxic agents that induce death of rat cardiac myoblast H9c2 cells and isolated rat cardiomyocytes. We found that the cardiotoxic agents tert-Butyl hydroperoxide (tBHP, organic reactive oxygen species (ROS) inducer), sodium nitroprusside (SNP; anti-hypertension drug), and doxorubicin (anti-cancer drug) caused mitochondrial dysfunction such as increased ROS level and decreased mitochondrial membrane potential. Co-treatment with Ech A, however, prevented this decrease in membrane potential and increase in ROS level. Co-treatment of Ech A also reduced the effects of these cardiotoxic agents on mitochondrial oxidative phosphorylation and adenosine triphosphate level. These findings indicate the therapeutic potential of Ech A for reducing cardiotoxic agent-induced damage.
- Subjects :
- Adenosine Triphosphate metabolism
Animals
Cardiotoxins toxicity
Cell Death drug effects
Membrane Potential, Mitochondrial drug effects
Mitogen-Activated Protein Kinases antagonists & inhibitors
Mitogen-Activated Protein Kinases metabolism
Rats
Reactive Oxygen Species metabolism
Sea Urchins
Cardiotonic Agents pharmacology
Cardiotoxins antagonists & inhibitors
Mitochondria, Heart drug effects
Myocytes, Cardiac drug effects
Naphthoquinones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 24828295
- Full Text :
- https://doi.org/10.3390/md12052922