Back to Search
Start Over
Pneumonia and the incidence of cancer: a Danish nationwide cohort study.
- Source :
-
Journal of internal medicine [J Intern Med] 2015 Apr; Vol. 277 (4), pp. 429-38. Date of Electronic Publication: 2014 May 27. - Publication Year :
- 2015
-
Abstract
- Objectives: To examine the risk of a subsequent pulmonary or extra-pulmonary cancer diagnosis following a first-time hospital-based diagnosis of pneumonia.<br />Design: Population-based cohort study using Danish medical registries.<br />Setting: All hospitals in Denmark.<br />Subjects: A total of 342,609 patients with a first-time hospital-based (inpatient, emergency room or outpatient clinic) diagnosis of pneumonia between 1995 and 2011.<br />Main Outcome Measures: We quantified the excess risk of various cancers amongst pneumonia patients compared to the expected risk in the general population, using relative [standardised incidence ratios (SIRs)] and absolute risk calculations. Follow-up started 1 month after a hospital-based diagnosis of pneumonia and ended on 31 December 2011.<br />Results: A total of 28,496 cancers were observed, compared with 21,625 expected, amongst 342,609 pneumonia patients followed for a median of 4.2 years. The absolute risk of a cancer diagnosis 1 to <6 months following a pneumonia diagnosis was 1.4%, with a corresponding SIR of 2.48 [95% confidence interval (CI) 2.41-2.55]. This was mainly due to an increased risk of lung cancer (eightfold) and haematological cancers (fourfold). The SIR for any cancer remained increased at 1.35 (95% CI 1.30-1.40) during 6-12 months of follow-up, and 1.20 (95% CI 1.18-1.22) during 1-5 years of follow-up. Beyond 5 years, an increased risk was maintained for lung, oesophageal, liver and bladder cancers, squamous cell carcinoma of the skin, lymphoma and multiple myeloma.<br />Conclusions: A hospital-based pneumonia diagnosis was associated with an increased risk of a cancer diagnosis, especially in the ensuing months, but the absolute risk was small.<br /> (© 2014 The Association for the Publication of the Journal of Internal Medicine.)
Details
- Language :
- English
- ISSN :
- 1365-2796
- Volume :
- 277
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24831031
- Full Text :
- https://doi.org/10.1111/joim.12270