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IL-22 gets to the stem of colorectal cancer.

Authors :
Koltsova EK
Grivennikov SI
Source :
Immunity [Immunity] 2014 May 15; Vol. 40 (5), pp. 639-41.
Publication Year :
2014

Abstract

Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1097-4180
Volume :
40
Issue :
5
Database :
MEDLINE
Journal :
Immunity
Publication Type :
Academic Journal
Accession number :
24837100
Full Text :
https://doi.org/10.1016/j.immuni.2014.04.014