Unintentional lethal overdose with metildigoxin in a 36-week-old infant--post mortem tissue distribution of metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry.

Authors :: Hess C
Brockmann C
Doberentz E
Madea B
Musshoff F
Source :: Forensic science international [Forensic Sci Int] 2014 Aug; Vol. 241, pp. e23-7. Date of Electronic Publication: 2014 May 24.
Publication Year :: 2014
Abstract: A massive lethal overdose with beta-metildigoxin in a 36-week-old infant is presented. Determination of beta-metildigoxin and its metabolites digoxin, digoxigenin and digoxigenin-monodigitoxosid is achieved by a liquid chromatographic mass spectrometric (LC-MS/MS) method. Measured concentrations for beta-metildigoxin and digoxin in peripheral blood were 40.2 ng/ml and 25.6 ng/ml, respectively. Tissue distribution showed highest concentrations in kidney tissue and gastric content. The metabolite digoxigenin-monodigitoxosid could be detected in heart blood, duodenal content, gastric content and fat tissue while the metabolite digoxigenin could only be detected in gastric content since the drug was given by a stomach tube.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Cardiotonic Agents administration & dosage
Chromatography, Liquid
Digoxigenin analogs & derivatives
Digoxigenin pharmacokinetics
Digoxin pharmacokinetics
Drug Overdose
Forensic Toxicology
Humans
Hypertension, Pulmonary therapy
Infant
Male
Medigoxin administration & dosage
Tandem Mass Spectrometry
Tissue Distribution
Cardiotonic Agents pharmacokinetics
Cardiotonic Agents poisoning
Medication Errors
Medigoxin pharmacokinetics
Medigoxin poisoning

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