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Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.
- Source :
-
ACS medicinal chemistry letters [ACS Med Chem Lett] 2011 Mar 24; Vol. 2 (6), pp. 424-7. Date of Electronic Publication: 2011 Mar 24 (Print Publication: 2011). - Publication Year :
- 2011
-
Abstract
- Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. Inhibition of cholesteryl ester transfer protein (CETP) has been shown to elevate HDL-C levels in human subjects. This letter describes the discovery of a novel and potent (<100 nM IC50 for the inhibition of CE transfer) CETP inhibitor scaffold containing an oxazolidinone core.
Details
- Language :
- English
- ISSN :
- 1948-5875
- Volume :
- 2
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ACS medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 24900324
- Full Text :
- https://doi.org/10.1021/ml100309n