Back to Search Start Over

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases.

Authors :
Staderini M
Aulić S
Bartolini M
Tran HN
González-Ruiz V
Pérez DI
Cabezas N
Martínez A
Martín MA
Andrisano V
Legname G
Menéndez JC
Bolognesi ML
Source :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Dec 28; Vol. 4 (2), pp. 225-9. Date of Electronic Publication: 2012 Dec 28 (Print Publication: 2013).
Publication Year :
2012

Abstract

(E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both Aβ and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits Aβ self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test).

Details

Language :
English
ISSN :
1948-5875
Volume :
4
Issue :
2
Database :
MEDLINE
Journal :
ACS medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
24900645
Full Text :
https://doi.org/10.1021/ml3003605