Back to Search
Start Over
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
- Source :
-
ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Mar 12; Vol. 5 (5), pp. 485-90. Date of Electronic Publication: 2014 Mar 12 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Subglutinol A (1) is an immunosuppressive natural product isolated from Fusarium subglutinans, an endophytic fungus from the vine Tripterygium wilfordii. We show that 1 exerts multimodal immune-suppressive effects on activated T cells in vitro: subglutinol A (1) effectively blocks T cell proliferation and survival while profoundly inhibiting pro-inflammatory IFNγ and IL-17 production by fully differentiated effector Th1 and Th17 cells. Our data further reveal that 1 may exert its anti-inflammatory effects by exacerbating mitochondrial damage in T cells. Additionally, we demonstrate that 1 significantly reduces lymphocytic infiltration into the footpad and ameliorates footpad swelling in the mouse model of Th1-driven delayed-type hypersensitivity. These results suggest the potential of 1 as a novel therapeutic for inflammatory diseases.
Details
- Language :
- English
- ISSN :
- 1948-5875
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- ACS medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 24900866
- Full Text :
- https://doi.org/10.1021/ml4004809