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Effects of 5-amino salicylic acid on the expression of multidrug resistance gene in ulcerative colitis.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2014 Mar-Apr; Vol. 61 (130), pp. 367-72. - Publication Year :
- 2014
-
Abstract
- Background/aims: To study the effect of drugs on the expression of multidrug resistance gene in ulcerative colitis.<br />Methodology: The expressions of multidrug resistance (MDR) 1 gene and its product P-Gp were detected by reverse transcription-polymerase chain reaction and immunohistochemistry to realize the impact of drugs on ulcerative colitis.<br />Results: MDR1 gene and P-Gp did not exhibit significant difference (P > 0.05) before and after amino salicylic acid drug treatment. Compared with the control group, their expressions before treatment in the ineffective corticosteroid- and immunosuppressant-treated groups did not exhibit significant difference (P > 0.05). Their pre- and post-treatment expressions in the ineffective groups were compared with those in the normal control group and in the effective group, and significant differences were observed (P < 0.05).<br />Conclusions: 5-Amino salicylic acid drugs have little effect on the expression of MDR1 and its product P-Gp. The expressions of MDR1 and P-Gp were much higher in groups that showed ineffectiveness for corticosteroids and immunosuppressants after treatment.
- Subjects :
- ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1 genetics
Adolescent
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Case-Control Studies
Colitis, Ulcerative genetics
Female
Gene Expression drug effects
Glucocorticoids pharmacology
Humans
Immunohistochemistry
Immunosuppressive Agents pharmacology
Male
Middle Aged
Polymerase Chain Reaction
Young Adult
ATP Binding Cassette Transporter, Subfamily B, Member 1 biosynthesis
Colitis, Ulcerative metabolism
Mesalamine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 61
- Issue :
- 130
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 24901142