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Phenotypic profiles of virulence in different Candida species isolated from vulvovaginal infections.

Authors :
Sârbu I
Pelinescu D
Stoica I
Măruţescu L
Vassu T
Source :
Roumanian archives of microbiology and immunology [Roum Arch Microbiol Immunol] 2013 Oct-Dec; Vol. 72 (4), pp. 225-33.
Publication Year :
2013

Abstract

In order to establish an infection, pathogenic microorganisms have to colonize, survive, multiply, evade the immune system and spread to other tissues [1, 2, 3]. Although some Candida species are normally commensal in humans, in the last decades the frequency and the severity of nosocomial diseases due to Candida strains have increased dramatically [4]. The aim of the present study was to characterize some Candida strains isolated from vulvovaginal infections by determining the virulence and pathogenicity profile. The assessment of the in vitro expression of virulence cell wall associated factors (hyphal formation, adherence to HeLa cell line, biofilm development), soluble secreted enzymes (aspartyl protease, lipase, phospholipase, DN-ase) and Fe3+ accumulation was achieved by phenotypic methods on 13 yeast strains belonging to five Candida (C.) species (C. albicans, C. krusei, C. parapsilopsis, C. catenulata and C. kefyr). Candida sp. strains isolated from vulvovaginal infections showed species/ strain specific virulence profile.

Details

Language :
English
ISSN :
1222-3891
Volume :
72
Issue :
4
Database :
MEDLINE
Journal :
Roumanian archives of microbiology and immunology
Publication Type :
Academic Journal
Accession number :
24923105