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Biomarkers of bone metabolism in ankylosing spondylitis in relation to osteoproliferation and osteoporosis.
- Source :
-
The Journal of rheumatology [J Rheumatol] 2014 Jul; Vol. 41 (7), pp. 1349-56. - Publication Year :
- 2014
-
Abstract
- Objective: To identify biomarkers for bone metabolism in patients with ankylosing spondylitis (AS) and to determine the relationship between these biomarkers and disease activity, back mobility, osteoproliferation, and bone mineral density (BMD).<br />Methods: Serum levels of Wingless protein (Wnt-3a), Dickkopf-1 (DKK-1), sclerostin, soluble receptor activator of nuclear factor-κB ligand (sRANKL), and osteoprotegerin were assessed using ELISA. Ankylosing Spondylitis Disease Activity Score-C reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis patient global score, and C-reactive protein (CRP) were used as disease activity measures, and Bath Ankylosing Spondylitis Metrology Index (BASMI) as a measure of spinal mobility. Lateral spine radiographs were scored for chronic AS-related changes (mSASSS). BMD was measured with dual-energy x-ray absorptiometry.<br />Results: Two hundred four patients with AS (NY criteria; 57% men), with a mean age of 50 ± 13 years and disease duration 15 ± 11 years, and 80 age and sex-matched controls were included. The patients with AS had significantly higher serum levels of Wnt-3a (p < 0.001) and lower levels of sclerostin (p = 0.014) and sRANKL (p = 0.047) compared with the controls. High CRP was associated with low sclerostin (r(S) = -0.21, p = 0.003) and DKK-1 (r(S) = -0.14, p = 0.045). In multiple linear regression analyses, increasing BASMI and mSASSS were independently associated with older age, male sex, high CRP, and elevated serum levels of Wnt-3a. In addition, mSASSS remained associated with a high number of smoking pack-years after adjusting for age. Low BMD of femoral neck was associated with high mSASSS after adjusting for age.<br />Conclusion: Serum levels of Wnt-3a are elevated in AS and associated with increased BASMI and mSASSS, independent of age, indicating that Wnt-3a could be a biomarker for the osteoproliferative process.
- Subjects :
- Adaptor Proteins, Signal Transducing
Adolescent
Adult
Aged
Biomarkers blood
Bone Morphogenetic Proteins blood
Female
Genetic Markers
Humans
Male
Middle Aged
Osteoporosis blood
Osteoporosis etiology
Osteoprotegerin blood
RANK Ligand blood
Severity of Illness Index
Spondylitis, Ankylosing complications
Wnt3A Protein blood
Young Adult
Bone Density physiology
Bone and Bones metabolism
Osteoporosis diagnosis
Spondylitis, Ankylosing blood
Subjects
Details
- Language :
- English
- ISSN :
- 0315-162X
- Volume :
- 41
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 24931960
- Full Text :
- https://doi.org/10.3899/jrheum.131199