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Diabetes mellitus increases risk for colorectal adenomas in younger patients.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2014 Jun 14; Vol. 20 (22), pp. 6946-52. - Publication Year :
- 2014
-
Abstract
- Aim: To determine if diabetes mellitus (DM) is associated with increased risk of colorectal adenomas in younger subjects.<br />Methods: This was a retrospective cohort study of 375 patients undergoing index colonoscopy at a single tertiary care center in the United States. Three cohorts of patients matched for exam date and gender were compared: (1) ages 40-49 years with DM; (2) ages 40-49 years without DM; and (3) ages 50-59 years without DM. Data collected included demographics, co-morbidities, colonoscopy and pathology results. Adenoma detection rates (ADR) were calculated and compared. Conditional logistic regression analysis was performed to determine the association between each cohort and ADR.<br />Results: One hundred and twenty-five patients ages 40-49 with DM met study eligibility criteria. Patients in the other two cohorts were randomly selected, matching for date of exam and gender. ADR was 14.4% in those ages 40-49 years without DM, 30.4% in those ages 40-49 years with DM, and 32.0% in those ages 50-59 years without DM. Compared to those ages 40-49 years without DM, ADR was higher in those ages 40-49 years with DM (OR = 3.1; 95%CI: 1.5-6.4; P = 0.002) and those ages 50-59 years without DM (OR = 2.9; 95%CI: 1.5-5.6; P = 0.002). There was no difference between the ADR in those ages 40-49 years with DM and those ages 50-59 years without DM (P = 0.83).<br />Conclusion: DM was associated with higher risk of colorectal adenomas in patients ages 40-49 years. These subjects harbored as many adenomas as those at the standard screening age of 50-59 years without DM.
- Subjects :
- Adenoma diagnosis
Adult
Age Factors
Chi-Square Distribution
Colonic Polyps diagnosis
Colonoscopy
Colorectal Neoplasms diagnosis
Comorbidity
Diabetes Mellitus diagnosis
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prevalence
Retrospective Studies
Risk Factors
Tertiary Care Centers
Washington epidemiology
Adenoma epidemiology
Colonic Polyps epidemiology
Colorectal Neoplasms epidemiology
Diabetes Mellitus epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 20
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 24944487
- Full Text :
- https://doi.org/10.3748/wjg.v20.i22.6946