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Long-term hearing loss after chemoradiation in patients with head and neck cancer.
- Source :
-
The Laryngoscope [Laryngoscope] 2014 Dec; Vol. 124 (12), pp. 2720-5. Date of Electronic Publication: 2014 Jun 26. - Publication Year :
- 2014
-
Abstract
- Objectives/hypothesis: The purpose of this study was to determine whether concomitant chemoradiation (CCRT)-induced hearing loss is progressive over time or not.<br />Study Design: Long-term (LT) follow-up study.<br />Methods: Between 1999 and 2004, 158 patients with head and neck cancer were treated with intravenous (IV) CCRT (nā=ā80) or intraarterial CCRT (nā=ā78). Audiometry was performed before, short-term (ST), and LT posttreatment. Differences in hearing were assessed with a multivariable linear regression analysis, incorporating the effect of aging.<br />Results: Long-term audiometry (median 4.5 years) was available in 67 patients (42%). At ST follow-up, a deterioration of 21.6 decibel was seen compared to baseline at pure-tone averages (PTA) 8-10-12.5 kHz. At LT follow-up, this deterioration further increased with 5 decibel (P = 0.005). Only in CCRT-IV patients was a significant progressive treatment-induced hearing loss seen, at PTA 8-10-12.5 kHz (P = 0.005), PTA 1-2-4 kHz air conduction (P = 0.014), and PTA 0.5-1-2 kHz bone conduction (P = 0.045).<br />Conclusion: CCRT-induced hearing impairment was progressive over time, especially in higher frequencies and only in CCRT-IV patients, with a modest deterioration of 5 decibel 4.5 years post-treatment.<br />Level of Evidence: 4.<br /> (© 2014 The American Laryngological, Rhinological and Otological Society, Inc.)
- Subjects :
- Adult
Aged
Audiometry, Pure-Tone
Auditory Threshold physiology
Chemoradiotherapy adverse effects
Female
Follow-Up Studies
Hearing Loss diagnosis
Hearing Loss epidemiology
Humans
Incidence
Male
Middle Aged
Netherlands epidemiology
Retrospective Studies
Time Factors
Antineoplastic Agents adverse effects
Forecasting
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms radiotherapy
Hearing physiology
Hearing radiation effects
Hearing Loss etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-4995
- Volume :
- 124
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Laryngoscope
- Publication Type :
- Academic Journal
- Accession number :
- 24964759
- Full Text :
- https://doi.org/10.1002/lary.24802