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Anti-inflammatory effects of polihexanide and polyethylene glycol in an in vitro study in chronic rhinosinusitis.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2014 Jul-Aug; Vol. 28 (4), pp. 489-94. - Publication Year :
- 2014
-
Abstract
- The majority of patients affected by chronic rhinosinusitis (CRS) suffer from eosinophilic infiltration. We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS. After obtaining samples from 10 CRS patients with (CRSwNP) and without nasal-polyposis (CRSsNP) and 2 patients with inverted-papilloma undergoing functional endoscopic sinus surgery (FESS), the expression of interleukin-5, eotaxin-3 and MMP-9 were evaluated by an ELISA assay with and without the tested agent. CRSwNP showed a significantly increased expression of IL-5. Polihexanide seems not to alter the attraction of eosinophils in patients with CRS via IL-5 expression. Also elevated levels of MMP-9 could not be reduced to normal values. But there exists statistically significant evidence that the self-amplification process of eosinophils via eotaxin-3 could be influenced by the administration of polihexanide.<br /> (Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Subjects :
- Cells, Cultured
Chemokine CCL26
Chemokines, CC metabolism
Chronic Disease
Fibroblasts drug effects
Fibroblasts metabolism
Humans
Interleukin-5 metabolism
Matrix Metalloproteinase 9 metabolism
Nasal Mucosa drug effects
Nasal Mucosa metabolism
Nasal Polyps complications
Rhinitis complications
Sinusitis complications
Anti-Inflammatory Agents pharmacology
Biguanides pharmacology
Polyethylene Glycols pharmacology
Rhinitis metabolism
Sinusitis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 28
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 24982214