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Anti-inflammatory effects of polihexanide and polyethylene glycol in an in vitro study in chronic rhinosinusitis.

Authors :
Birk R
Grossbaier J
Aderhold C
Stern-Sträter J
Hörmann K
Sauter A
Sommer JU
Source :
In vivo (Athens, Greece) [In Vivo] 2014 Jul-Aug; Vol. 28 (4), pp. 489-94.
Publication Year :
2014

Abstract

The majority of patients affected by chronic rhinosinusitis (CRS) suffer from eosinophilic infiltration. We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS. After obtaining samples from 10 CRS patients with (CRSwNP) and without nasal-polyposis (CRSsNP) and 2 patients with inverted-papilloma undergoing functional endoscopic sinus surgery (FESS), the expression of interleukin-5, eotaxin-3 and MMP-9 were evaluated by an ELISA assay with and without the tested agent. CRSwNP showed a significantly increased expression of IL-5. Polihexanide seems not to alter the attraction of eosinophils in patients with CRS via IL-5 expression. Also elevated levels of MMP-9 could not be reduced to normal values. But there exists statistically significant evidence that the self-amplification process of eosinophils via eotaxin-3 could be influenced by the administration of polihexanide.<br /> (Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Details

Language :
English
ISSN :
1791-7549
Volume :
28
Issue :
4
Database :
MEDLINE
Journal :
In vivo (Athens, Greece)
Publication Type :
Academic Journal
Accession number :
24982214