Synthesis, antimicrobial and anticancer evaluation of N'-(substituted benzylidene)-2-(benzo[d]oxazol-3(2H)-yl)acetohydrazide derivatives.

Authors :: Rohilla P
Deep A
Kamra M
Narasimhan B
Ramasamy K
Mani V
Mishra RK
Lim SM
Source :: Drug research [Drug Res (Stuttg)] 2014 Oct; Vol. 64 (10), pp. 505-9. Date of Electronic Publication: 2014 Jul 03.
Publication Year :: 2014
Abstract: A series of N'-(substituted benzylidene)-2-(benzo[d]oxazol-3(2H)-yl)acetohydrazide derivatives was synthesized and evaluated for its in vitro antimicrobial and anticancer activities. Antimicrobial activity results revealed that compound 12 was found to be the most potent antimicrobial agent. Results of anticancer study indicated that the synthesized compounds exhibited average anticancer potential. Compound 7 (IC 50 =3.12 µM) and compound 16 (IC 50 =2.88 µM) were found to be most potent against breast cancer (MCF7) cell lines. In conclusion, compound 12 and 16 have the potential to be selected as lead compound for the developing of novel antimicrobial and anticancer agents respectively.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)

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